PTH 1-84 and PTH "7-84" in the noninvasive diagnosis of renal bone disease.

  title={PTH 1-84 and PTH "7-84" in the noninvasive diagnosis of renal bone disease.},
  author={Giorgio M Coen and Ermanno Bonucci and Paola Ballanti and Alessandro Balducci and Santo Calabria and Giulia Adriana Nicolai and Maria Fischer and Francesca Lifrieri and Micaela Manni and Massimo Morosetti and Eleonora Moscaritolo and Daniela Sardella},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  volume={40 2},
BACKGROUND The intact parathyroid hormone (PTH) assay evaluates levels of serum 1-84 PTH and other N-terminally truncated PTH fragments, mainly PTH "7-84." This PTH molecule has been found experimentally to interfere with biological activity of PTH 1-84, perhaps through its binding to the PTH receptor complex. Therefore, assuming that high levels of PTH 7-84 are a cause of bone resistance to PTH, it has been hypothesized that a decreased 1-84 to 7-84 PTH ratio caused by a relative increase in… CONTINUE READING
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