PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism.

  title={PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism.},
  author={Mishaela R. Rubin and David W. Dempster and James Sliney and Hua Zhou and Thomas L Nickolas and Emily M. Stein and Elzbieta Dworakowski and Maryann Dellabadia and Rebecca L. Ives and Donald J McMahon and Chiyuan Zhang and Shonni J. Silverberg and Elizabeth Shane and Serge C. L. M. Cremers and John P. Bilezikian},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={26 11},
Hypoparathyroidism is associated with abnormal structural and dynamic skeletal properties. We hypothesized that parathyroid hormone(1-84) [PTH(1-84)] treatment would restore skeletal properties toward normal in hypoparathyroidism. Sixty-four subjects with hypoparathyroidism were treated with PTH(1-84) for 2 years. All subjects underwent histomorphometric assessment with percutaneous iliac crest bone biopsies. Biopsies were performed at baseline and at 1 or 2 years. Another group of subjects had… CONTINUE READING
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