PTEN-regulated AKT/FoxO3a/Bim signaling contributes to Human cell glioblastoma apoptosis by platinum-maurocalcin conjugate.

@article{Aroui2016PTENregulatedAS,
  title={PTEN-regulated AKT/FoxO3a/Bim signaling contributes to Human cell glioblastoma apoptosis by platinum-maurocalcin conjugate.},
  author={Sonia Aroui and Lucie Dardevet and Feten Najlaoui and Meriem Kammoun and Amel Laajimi and Hamadi Fetoui and Michel De Waard and Abderraouf Kenani},
  journal={The international journal of biochemistry & cell biology},
  year={2016},
  volume={77 Pt A},
  pages={
          15-22
        }
}
A previous report has shown that a chimera between a platinum complexing agent (1) and the cell penetrating peptide maurocalcin, synthesized with D-amino acids, (DMCa), termed Pt-1-DMCa, is a highly successful anticancer compound that works by targeting the intracellular redox system in glioblastoma (GBM) cells. However, the detailed cellular mechanism whereby the conjugate specifically kills tumor cells remains unclear. Herein, we show that Pt-1-DMCa induces apoptosis in Human U87 GBM cells… CONTINUE READING
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