PTEN reduces cuff-induced neointima formation and proinflammatory cytokines.

  title={PTEN reduces cuff-induced neointima formation and proinflammatory cytokines.},
  author={Shinichiro Koide and Masahiro Okazaki and Masahito Tamura and Kiyoshi Ozumi and Hiroyuki Takatsu and Fumihiko Kamezaki and Akihide Tanimoto and Hiromi Tasaki and Yasuyuki Sasaguri and Yasuhide Nakashima and Yutaka Otsuji},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={292 6},
An inflammatory response followed by vascular injury plays an important role in neointima formation and development of atherosclerotic lesions, which are in part mediated by proinflammatory cytokines. Using a cuff injury model, we examined the effects of adenovirus-mediated overexpression of phosphatase and tensin homology deleted on chromosome 10 (PTEN) on neointima formation and the proinflammatory response. A cuff was placed around the femoral artery, and adenovirus expressing human PTEN… CONTINUE READING
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Angiotensin-converting enzyme inhibitor restrains inflam H2830 PTEN REDUCES NEOINTIMA FORMATION AND CYTOKINES AJP-Heart Circ Physiol

  • M Akishita, G Shirakami, +5 authors M. Horiuchi
  • J Hypertens
  • 2007
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