PTEN promoter methylation and protein expression in normal early placentas and hydatidiform moles.

OBJECTIVE To investigate the relationship between PTEN promoter methylation and protein expression, and the possible involvement of the PTEN gene in development of gestational trophoblasts and the pathogenesis of hydatidiform moles. METHODS DNA was extracted from choria of normal early placentas, partial hydatidiform moles, complete hydatidiform moles… CONTINUE READING