PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma.

@article{Uegaki2005PTENpositiveAP,
  title={PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma.},
  author={Kazunori Uegaki and Yasunobu Kanamori and Junzo Kigawa and Wakae Kawaguchi and Ruri Kaneko and Jun Naniwa and Masakuni Takahashi and Muneaki Shimada and Tetsuro Oishi and Hiroaki Itamochi and Naoki Terakawa},
  journal={Oncology reports},
  year={2005},
  volume={14 2},
  pages={
          389-92
        }
}
PTEN and the PI3K/Akt pathway are involved in the development and/or progression of endometrial carcinoma. To clarify the impact of the pathway-related molecules on prognosis, we analyzed PTEN, phosphorylated-Akt (p-Akt), and Ki-67 expression by immunohistochemistry in 99 patients with advanced endometrial carcinoma. PTEN-negative or PTEN-mixed staining was found in 66% of tumors. Positive staining of p-Akt was found in 40% of tumors. Loss of PTEN expression (negative or mixed) was… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 35 CITATIONS

Obesity is associated with higher 4E-BP1 expression in endometrial cancer

  • Current biomarker findings
  • 2014
VIEW 11 EXCERPTS
CITES RESULTS
HIGHLY INFLUENCED