PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes.

@article{Redfern2008PTENPS,
  title={PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes.},
  author={Roberta E Redfern and Duane Redfern and Melonnie L. M. Furgason and Mary Munson and Alonzo H. Ross and Arne Gericke},
  journal={Biochemistry},
  year={2008},
  volume={47 7},
  pages={2162-71}
}
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a tumor suppressor that is mutated or deleted in a variety of human tumors, and even loss of only one PTEN gene profoundly affects carcinogenesis. PTEN encodes a phosphatidylinositol phosphate phosphatase specific for the 3-position of the inositol ring. Despite its importance, we are just beginning to understand the regulatory circuits that maintain the correct levels of PTEN phosphatase activity. Several independent studies… CONTINUE READING

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