PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression.

@article{Chang2008PTENNL,
  title={PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression.},
  author={Chun-Ju Chang and David J. Mulholland and Bahram Valamehr and Sherly Mosessian and William R. Sellers and Hong Wu},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 10},
  pages={
          3281-9
        }
}
The tumor suppressor gene PTEN (phosphatase and tensin homologue deleted on chromosome 10) is frequently mutated or deleted in various human cancers. PTEN localizes predominantly to the cytoplasm and functions as a lipid phosphatase, thereby negatively regulating the phosphatidylinositol 3-kinase-AKT signaling pathway. PTEN can also localize to the nucleus, where it binds and regulates p53 protein level and transcription activity. However, the precise function of nuclear PTEN and the factors… CONTINUE READING

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