PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas.

@article{Wappenschmidt2004PTENMD,
  title={PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas.},
  author={Barbara Wappenschmidt and Eva Wardelmann and Andrea E. Gehrig and Thomas Sch{\"o}ndorf and Nicola{\`i} Maass and G. Bonatz and A Gassel and Thorsten Pietsch and Priv. Doz. Dr. P. Mallmann and Bernhard H. F. Weber and Rita Katharina Schmutzler},
  journal={Human pathology},
  year={2004},
  volume={35 10},
  pages={1260-5}
}
PTEN: and beta-catenin mutations constitute the predominant genetic alterations in endometrioid carcinomas of the endometrium. PTEN encodes a dual-specificity phosphatase with lipid phosphatase and protein tyrosine phosphatase activities that regulate both apoptosis and interactions with the extracellular matrix. Recent studies have associated PTEN mutations with tumorigenesis of prostate carcinoma via the Wnt signaling pathway, leading to nuclear beta-catenin accumulation. To elucidate the… CONTINUE READING

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