PTEN mutations and evolving concepts in endometrial neoplasia.

  title={PTEN mutations and evolving concepts in endometrial neoplasia.},
  author={Eleanor Latta and William B. Chapman},
  journal={Current opinion in obstetrics & gynecology},
  volume={14 1},
Several recent advances have been made in our understanding of the pathogenesis of endometrial tumours, particularly endometrioid endometrial carcinoma (EEC). Mutations in the PTEN gene and microsatellite instability (MSI) are common genetic abnormalities in EECs, and distinguish these lesions from other histological subtypes of endometrial carcinoma. Endometrial precancers are monoclonal lesions that share a common genetic lineage with invasive EEC, including PTEN mutations and MSI. Mutations… CONTINUE READING

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