PTEN loss and ERG protein expression are infrequent in prostatic ductal adenocarcinomas and concurrent acinar carcinomas.

@article{Morais2015PTENLA,
  title={PTEN loss and ERG protein expression are infrequent in prostatic ductal adenocarcinomas and concurrent acinar carcinomas.},
  author={Carlos L. Morais and Mehsati Herawi and Antoun Toubaji and Roula Albadine and Jessica L. Hicks and George J Netto and Angelo M De Marzo and Jonathan I. Epstein and Tamara L Lotan},
  journal={The Prostate},
  year={2015},
  volume={75 14},
  pages={1610-9}
}
BACKGROUND Prostatic ductal adenocarcinoma is an unusual and aggressive morphologic subtype of prostate cancer. PTEN gene deletion and ERG gene rearrangement are among the most common genomic changes in acinar prostate cancers. Though ductal adenocarcinoma most commonly occurs with synchronous usual-type acinar adenocarcinoma, little is known about the molecular phenotype of these mixed tumors. METHODS We used genetically validated immunohistochemistry (IHC) assays to assess PTEN and ERG… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 67 references

PTEN Status Determination in Prostate Cancer: Comparison of IHC and FISH in a Large Multi-Center Cohort

  • T Lotan, C Morais, +7 authors J. Squire
  • Mod Pathol 2015;28:241A
  • 2015
2 Excerpts

Heterogeneity and chronology of PTEN deletion and ERG fusion in prostate cancer

  • A Krohn, F Freudenthaler, +14 authors S. Minner
  • Mod Pathol
  • 2014

cancer

  • M Herawi, JI Epstein
  • 2014

Similar Papers

Loading similar papers…