PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression.

@article{Jurado2010PTENIR,
  title={PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression.},
  author={Sandra Jurado and Marion Benoist and Argentina Lario and Shira Knafo and Cortney N. Petrok and Jos{\'e} A Esteban},
  journal={The EMBO journal},
  year={2010},
  volume={29 16},
  pages={2827-40}
}
Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is an important regulator of phosphatidylinositol-(3,4,5,)-trisphosphate signalling, which controls cell growth and differentiation. However, PTEN is also highly expressed in the adult brain, in which it can be found in dendritic spines in hippocampus and other brain regions. Here, we have investigated specific functions of PTEN in the regulation of synaptic function in excitatory hippocampal synapses. We found that NMDA receptor… CONTINUE READING