PTEN inhibition enhances neurite outgrowth in human embryonic stem cell–derived neuronal progenitor cells

@article{Wyatt2014PTENIE,
  title={PTEN inhibition enhances neurite outgrowth in human embryonic stem cell–derived neuronal progenitor cells},
  author={Lindsey A Wyatt and Marie T. Filbin and Hans Keirstead},
  journal={Journal of Comparative Neurology},
  year={2014},
  volume={522}
}
We investigated the role of PTEN (phosphatase and tensin homolog deleted on chromosome 10) during neurite outgrowth of human embryonic stem cell (hESC)‐derived neuronal progenitors. PTEN inhibits phosphoinositide 3‐kinase (PI3K)/Akt signaling, a common and central outgrowth and survival pathway downstream of neuronal growth factors. It is known that PTEN inhibition, by either polymorphic mutation or gene deletion, can lead to the development of tumorigenesis (Stambolic et al., ; Tamura et al… 
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