PTEN inhibition enhances neurite outgrowth in human embryonic stem cell–derived neuronal progenitor cells

@article{Wyatt2014PTENIE,
  title={PTEN inhibition enhances neurite outgrowth in human embryonic stem cell–derived neuronal progenitor cells},
  author={Lindsey A Wyatt and Marie T. Filbin and Hans Keirstead},
  journal={Journal of Comparative Neurology},
  year={2014},
  volume={522}
}
We investigated the role of PTEN (phosphatase and tensin homolog deleted on chromosome 10) during neurite outgrowth of human embryonic stem cell (hESC)‐derived neuronal progenitors. PTEN inhibits phosphoinositide 3‐kinase (PI3K)/Akt signaling, a common and central outgrowth and survival pathway downstream of neuronal growth factors. It is known that PTEN inhibition, by either polymorphic mutation or gene deletion, can lead to the development of tumorigenesis (Stambolic et al., ; Tamura et al… 
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Mechanistic insight is provided into how MOB1 acts as a novel and a necessary regulator in PTEN–GSK3β axis that controls neurite outgrowth after SCI.
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TLDR
A mouse model of SCI is constructed, extracted RNA from injured spinal cord tissue for the use of microarray assay and miR‐181d‐5p, one of the most significantly expressed miRNAs in miRNA‐mRNA network, abundantly expressed in center system and highly conserved across different spices, was chosen for further study.
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TLDR
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HOXA6 inhibits cell proliferation and induces apoptosis by suppressing the PI3K/Akt signaling pathway in clear cell renal cell carcinoma
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It is demonstrated that HOXA6 suppresses cell proliferation and promotes apoptosis, which may occur via inhibition of the PI3K/Akt/ERK cascade, and the role of HOxA6 in ccRCC is indicated.
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TLDR
The purpose of this review is to summarize the research progress of PI3K/Akt signaling pathway in erythropoiesis and glycolysis and identify the key proteins involved in cell proliferation, apoptosis inhibition, cell migration, vesicle transport and cell cancerous transformation.
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All studies included in this systematic review indicated that pharmacological inhibition of PTEN enhanced the repair process of the eye, lung, muscle and nervous system.
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