PTEN immunohistochemical expression is suppressed in G1 endometrioid adenocarcinoma of the uterine corpus

@article{Kimura2003PTENIE,
  title={PTEN immunohistochemical expression is suppressed in G1 endometrioid adenocarcinoma of the uterine corpus},
  author={Fumio Kimura and Jun Watanabe and Hiroki Hata and Takeshi Fujisawa and Yuko Kamata and Yukari Nishimura and Toshiko Jobo and Hiroyuki Kuramoto},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2003},
  volume={130},
  pages={161-168}
}
PTEN is a tumor suppressor gene that inhibits cell proliferation by regulating intracellular signaling pathways, and this activity can be abolished by mutations of the PTEN gene. This study was designed to examine the correlation of PTEN expression with the expression of cell cycle regulators and with clinicopathological parameters in endometrioid adenocarcinoma of the uterine corpus. Tissue samples of 117 endometrioid adenocarcinomas in addition to those of 19 normal endometria and 20… CONTINUE READING

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