PTEN gene mutations in colorectal cancers displaying microsatellite instability.

@article{Shin2001PTENGM,
  title={PTEN gene mutations in colorectal cancers displaying microsatellite instability.},
  author={Kim Hyung Shin and Yeung Jun Park and J. G. Park},
  journal={Cancer letters},
  year={2001},
  volume={174 2},
  pages={
          189-94
        }
}
To determine the relationship between the mutation of the PTEN gene and genomic instability in human colorectal cancer, we screened the PTEN gene in 32 colorectal cancers (eight cell lines and 24 tissues) displaying microsatellite instability (MSI) and 32 colorectal cancers (six cell lines and 26 tissues) displaying microsatellite stability (MSS). Of 64 samples, six frameshift mutations were identified in six MSI colorectal cancers (two cell lines and four tumor tissues) but not in MSS… CONTINUE READING
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