PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

@article{Heit2008PTENFT,
  title={PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils},
  author={Bryan Heit and Stephen M. Robbins and Charlene M. Downey and Zhiwen Guan and P. J. Colarusso and Barbara J Miller and Frank Robert Jirik and Paul Kubes},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={743-752}
}
Neutrophils encounter and 'prioritize' many chemoattractants in their pursuit of bacteria. Here we tested the possibility that the phosphatase PTEN is responsible for the prioritization of chemoattractants. Neutrophils induced chemotaxis by two separate pathways, the phosphatidylinositol-3-OH kinase (PI(3)K) phosphatase and tensin homolog (PTEN) pathway, and the p38 mitogen-activated protein kinase pathway, with the p38 pathway dominating over the PI(3)K pathway. Pten−/− neutrophils could not… CONTINUE READING

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