PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma.

  title={PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma.},
  author={James V Lacey and George L. Mutter and Brigitte M. Ronnett and Olga B. Ioffe and M{\'a}ire A. Duggan and Brenda B. Rush and Andrew Glass and Douglas A. Richesson and Nilanjan Chatterjee and Bryan Langholz and Mark E. Sherman},
  journal={Cancer research},
  volume={68 14},
Inactivation of PTEN tumor suppressor gene is common in endometrial carcinoma and its precursor, atypical endometrial hyperplasia (EH). We compared PTEN expression via immunohistochemistry in endometrial biopsies diagnosed as EH in 138 cases, who were diagnosed with EH and then endometrial carcinoma at least 1 year later (median, 6 years), and 241 individually matched controls, who were diagnosed with EH but did not progress to carcinoma during equivalent follow-up. We assessed PTEN status… CONTINUE READING

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