PTEN deletion is rare but often homogeneous in gastric cancer.

  title={PTEN deletion is rare but often homogeneous in gastric cancer.},
  author={Sormeh Mina and Benjamin Alexander Bohn and Ronald Simon and Antje Krohn and Matthias Reeh and D. I. Arnold and C Carsten Bokemeyer and Guido Sauter and Jakob Robert Izbicki and Andreas Marx and Phillip R Stahl},
  journal={Journal of clinical pathology},
  volume={65 8},
BACKGROUND AND AIM Gastric carcinoma is the second most frequent cause of cancer-related death worldwide. As PTEN is a potential modifier of tumour response to trastuzumab, a recently approved therapy in metastatic HER2 positive gastric cancer, the existence of PTEN deletions in primary gastric cancer was investigated. METHODS 230 primary gastric cancers were analysed in a tissue microarray format by dual labelling fluorescence in situ hybridisation for PTEN deletion. HER2 analysis was also… CONTINUE READING
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  • NS Darwish, MA Kim, MS Chang
  • BMC Gastroenterol
  • 2010

Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI 3 K / AKT pathway

  • JY Wu
  • Oncol Rep
  • 2010

PTEN , PIK 3 CA , p - AKT , and pp 70 S 6 K status : association with trastuzumab response and survival in patients with HER 2 - positive metastatic breast cancer

  • FJ Esteva, H Guo, S Zhang
  • Am J Pathol
  • 2010

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