PTEN deletion is rare but often homogeneous in gastric cancer.

@article{Mina2012PTENDI,
  title={PTEN deletion is rare but often homogeneous in gastric cancer.},
  author={Sormeh Mina and Benjamin Alexander Bohn and Ronald Simon and Antje Krohn and Matthias Reeh and D. I. Arnold and C Carsten Bokemeyer and Guido Sauter and Jakob Robert Izbicki and Andreas Marx and Phillip R Stahl},
  journal={Journal of clinical pathology},
  year={2012},
  volume={65 8},
  pages={693-8}
}
BACKGROUND AND AIM Gastric carcinoma is the second most frequent cause of cancer-related death worldwide. As PTEN is a potential modifier of tumour response to trastuzumab, a recently approved therapy in metastatic HER2 positive gastric cancer, the existence of PTEN deletions in primary gastric cancer was investigated. METHODS 230 primary gastric cancers were analysed in a tissue microarray format by dual labelling fluorescence in situ hybridisation for PTEN deletion. HER2 analysis was also… CONTINUE READING
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