PTEN deficiency contributes to the development and progression of head and neck cancer.

@article{Squarize2013PTENDC,
  title={PTEN deficiency contributes to the development and progression of head and neck cancer.},
  author={Cristiane Helena Squarize and Rogerio Moraes Castilho and Aline Corr{\^e}a Abrah{\~a}o and Alfredo A Molinolo and Mark W. Lingen and J. Silvio Gutkind},
  journal={Neoplasia},
  year={2013},
  volume={15 5},
  pages={461-71}
}
The sequencing of the head and neck cancer has provided a blueprint of the most frequent genetic alterations in this cancer type. They include inactivating mutations in Notch, p53, and p16(ink4a) tumor suppressor genes, in addition to nonoverlapping activating mutations of the PIK3CA and RAS oncogenes or inactivation of the tumor suppressor gene PTEN. Notably, these genetic alterations, along with epigenetic changes, result in increased activity of phosphoinositide 3-kinase (PI3K)/AKT/mammalian… CONTINUE READING