PTEN deficiency: a role in mammary carcinogenesis

  title={PTEN deficiency: a role in mammary carcinogenesis},
  author={Teresa Petrocelli and Joyce M Slingerland},
  journal={Breast Cancer Research},
  pages={356 - 360}
The PTEN gene is often mutated in primary human tumors and cell lines, but the low rate of somatic PTEN mutation in human breast cancer has led to debate over the role of this tumor suppressor in this disease. The involvement of PTEN in human mammary oncogenesis has been implicated from studies showing that germline PTEN mutation in Cowden disease predisposes to breast cancer, the frequent loss of heterozygosity at the PTEN locus, and reduced PTEN protein levels in sporadic breast cancers. To… CONTINUE READING
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  • JA Diehl, M Cheng, MF Roussel, CJ Sherr
  • 2001

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