PTEN at a glance.

  title={PTEN at a glance.},
  author={Yuji Shi and Benjamin E. Paluch and X. Henry Wang and Xuejun Jiang},
  journal={Journal of cell science},
  volume={125 Pt 20},
Since its discovery in 1997 (Li and Sun, 1997; Li et al., 1997; Steck et al., 1997), the phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] phosphatase and tensin homolog (PTEN) has been established as one of the most frequently mutated tumor suppressor genes in human cancer. PTEN is a phosphatase that catalyzes the conversion of the lipid second messenger PtdIns (3,4,5)P3 to phosphatidylinositol (4,5)bisphosphate [PtdIns(4,5)P2] (Maehama and Dixon, 1998). As such, PTEN functions as a… CONTINUE READING
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