PTEN: a tumour suppressor that functions as a phospholipid phosphatase.

Abstract

The tumour suppressor PTEN has been implicated in a large number of human tumours and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, including phosphatidylinositol (3,4,5)-trisphosphate, and can therefore modulate signal-transduction… (More)

Topics

Cite this paper

@article{Maehama1999PTENAT, title={PTEN: a tumour suppressor that functions as a phospholipid phosphatase.}, author={Tomohiko Maehama and Jack E. Dixon}, journal={Trends in cell biology}, year={1999}, volume={9 4}, pages={125-8} }