PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.

  title={PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.},
  author={M J Georgescu},
  journal={Genes & cancer},
  volume={1 12},
The PI3K-Akt pathway is a major survival pathway activated in cancer. Efforts to develop targeted therapies have not been fully successful, mainly because of extensive internal intrapathway or external interpathway negative feedback loops or because of networking between pathway suppressors. The PTEN tumor suppressor is the major brake of the pathway and a common target for inactivation in somatic cancers. This review will highlight the networking of PTEN with other inhibitors of the pathway… CONTINUE READING