PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate

@inproceedings{Ferraldeschi2015PTENPL,
  title={PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate},
  author={Roberta Ferraldeschi and Daniel Nava Rodrigues and Ruth Riisnaes and Susana Miranda and In{\^e}s Pereira Figueiredo and Pasquale Rescigno and Praful Ravi and Carmel Pezaro and Aurelius G Omlin and David Lorente and Zafeiris Zafeiriou and Joaqu{\'i}n Ezpeleta Mateo and Amelia Altavilla and Spyridon Sideris and Diletta Bianchini and Emily Grist and Khin Thway and Raquel Perez Lopez and Nina Tunariu and Chris Parker and David P. Dearnaley and Alison H. M. Reid and Gerhardt Attard and Johann S de Bono},
  booktitle={European urology},
  year={2015}
}
BACKGROUND Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) occurs frequently in prostate cancers. Preclinical evidence suggests that activation of PI3K/AKT signaling through loss of PTEN can result in resistance to hormonal treatment in prostate cancer. OBJECTIVE To explore the antitumor activity of abiraterone acetate (abiraterone) in castration-resistant prostate cancer (CRPC) patients with and without loss of PTEN protein expression. DESIGN, SETTING, AND PARTICIPANTS… CONTINUE READING

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