PTEN-PDZ domain interactions: binding of PTEN to PDZ domains of PTPN13.

Abstract

Protein modular interactions mediated by PDZ domains are essential for the establishment of functional protein networks controlling diverse cellular functions. The tumor suppressor PTEN possesses a C-terminal PDZ-binding motif (PDZ-BM) that is recognized by a specific set of PDZ domains from scaffolding and regulatory proteins. Here, we review the current… (More)
DOI: 10.1016/j.ymeth.2014.10.017

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