PTEN Is Fundamental for Elimination of Leukemia Stem Cells Mediated by GSK126 Targeting EZH2 in Chronic Myelogenous Leukemia.

Abstract

Purpose: Leukemia stem cells (LSCs) are an important source of tyrosine kinase inhibitor resistance and disease relapse in patients with chronic myelogenous leukemia (CML). Targeting LSCs may be an attractive strategy to override this thorny problem. Given that EZH2 was overexpressed in primary CML CD34+ cells, our purpose in this study was to evaluate the… (More)
DOI: 10.1158/1078-0432.CCR-17-1533

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Cite this paper

@article{Zhou2017PTENIF, title={PTEN Is Fundamental for Elimination of Leukemia Stem Cells Mediated by GSK126 Targeting EZH2 in Chronic Myelogenous Leukemia.}, author={Jingfeng Zhou and Da-nian Nie and Juan Li and Xin Du and Yuhong Lu and Yangqiu Li and Cheng Chih Liu and Wei Dai and Yun Wang and Yanli Jin and Jingxuan Pan}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2017} }