PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines.

@article{Kondo2001PTENMMAC1TEP1MI,
  title={PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines.},
  author={Kenji Kondo and Ming Yao and Kazuyasu Kobayashi and Satoshi Ota and Masaaki Yoshida and Shuichi Kaneko and Masaya Baba and N Sakai and Takeshi Kishida and Shunsuke Kawakami and Hirotsugu Uemura and Yoji Nagashima and Yukio Nakatani and Masahiko Hosaka},
  journal={International journal of cancer},
  year={2001},
  volume={91 2},
  pages={219-24}
}
Extensive allelotyping studies have implicated several tumor-suppressor loci on chromosomes 3p, 5q, 6q, 8p, 9pq, 10q, 11q, 14q, 17p, 18q and 19p in human kidney tumorigenesis. The PTEN (also called MMAC1 and TEP1) gene, a candidate tumor suppressor located at chromosome 10q23.3, is mutated in a variety of sporadic malignancies as well as in patients with Cowden disease. To investigate the potential role of the PTEN gene in renal tumorigenesis, we searched for abnormalities of the gene in 68… CONTINUE READING

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