PTEN, more than the AKT pathway.

  title={PTEN, more than the AKT pathway.},
  author={Carmen Blanco-Aparicio and Oliver Renner and Juan F. M. Leal and Amancio Carnero},
  volume={28 7},
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/phosphatidylinositol 3-kinase (PI3K)/AKT constitute an important pathway regulating the signaling of multiple biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN is a dual protein/lipid phosphatase and its main substrate phosphatidyl-inositol 3,4,5 triphosphate (PIP3) is the product of PI3K. Increase in PIP3 recruits AKT to the membrane where is activated by other kinases also dependent on… CONTINUE READING
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PTEN enters the nuclear age

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