PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.

@article{Esteva2010PTENPP,
  title={PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.},
  author={Francisco J. Esteva and Hua Guo and Siyuan Zhang and Cesar Augusto Santa-Maria and Steven Stone and Jerry S. S. Lanchbury and Aysegul A. Sahin and Gabriel N Hortobagyi and Dihua Yu},
  journal={The American journal of pathology},
  year={2010},
  volume={177 4},
  pages={1647-56}
}
Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab sensitivity in HER2-overexpressing breast cancer. Because PTEN opposes the downstream signaling of phosphoinositide 3-kinase (PI3K), we investigated the role of PTEN and other components of the PI3K pathway in trastuzumab resistance. We analyzed the status of PTEN, p-AKT-Ser473, and p-p70S6K-Thr389 using immunohistochemistry. PIK3CA mutation status was analyzed by direct sequencing. Primary tumor tissue was available from… CONTINUE READING

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