PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer.

  title={PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer.},
  author={Anna Asplund and Anna C Gustafsson and N Wikonk{\'a}l and Aner Sela and David J. Leffell and Kara Kidd and Joakim Lundeberg and Douglas E. Brash and Fredrik Pont{\'e}n},
  journal={The British journal of dermatology},
  volume={152 5},
BACKGROUND The PTCH tumour suppressor gene is involved in the development of nearly all basal cell carcinomas (BCCs) of the skin and a fraction of squamous cell carcinomas (SCCs). A nonconservative Pro/Leu nucleotide polymorphism within PTCH exon 23 at codon 1315 was recently reported to be potentially important for the development of breast epithelial cell cancers. Objectives Accordingly, the status of PTCH codon 1315 was analysed for a possible association with the development of nonmelanoma… CONTINUE READING