PTBP1 modulation of MCL1 expression regulates cellular apoptosis induced by antitubulin chemotherapeutics

@article{Cui2016PTBP1MO,
  title={PTBP1 modulation of MCL1 expression regulates cellular apoptosis induced by antitubulin chemotherapeutics},
  author={Jiantao Cui and W. Placzek},
  journal={Cell Death and Differentiation},
  year={2016},
  volume={23},
  pages={1681-1690}
}
Myeloid cell leukemia sequence 1 (MCL1), an anti-apoptotic BCL2 family protein, is a key regulator of intrinsic apoptosis. Normal cells require strict control over MCL1 expression with aberrant MCL1 expression linked to the emergence of various diseases and chemoresistance. Previous studies have detailed how MCL1 expression is regulated by multiple mechanisms both transcriptionally and translationally. However, characterization of the post-transcriptional regulators of MCL1 mRNA is limited… CONTINUE READING