PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.

  title={PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.},
  author={Jonathan P Ling and Resham Chhabra and Jonathan D Merran and Paul M. Schaughency and Sarah J. Wheelan and Jeffry L. Corden and Philip Chuen Yung Wong},
  journal={Cell reports},
  volume={17 1},
The fidelity of RNA splicing is maintained by a network of factors, but the molecular mechanisms that govern this process have yet to be fully elucidated. We previously found that TDP-43, an RNA-binding protein implicated in neurodegenerative disease, utilizes UG microsatellites to repress nonconserved cryptic exons and prevent their incorporation into mRNA. Here, we report that two well-characterized splicing factors, polypyrimidine tract-binding protein 1 (PTBP1) and polypyrimidine tract… CONTINUE READING
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