PSSM-based prediction of DNA binding sites in proteins

  title={PSSM-based prediction of DNA binding sites in proteins},
  author={Shandar Ahmad and Akinori Sarai},
  journal={BMC Bioinformatics},
  pages={33 - 33}
Detection of DNA-binding sites in proteins is of enormous interest for technologies targeting gene regulation and manipulation. We have previously shown that a residue and its sequence neighbor information can be used to predict DNA-binding candidates in a protein sequence. This sequence-based prediction method is applicable even if no sequence homology with a previously known DNA-binding protein is observed. Here we implement a neural network based algorithm to utilize evolutionary information… CONTINUE READING
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