PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis

@article{Yeh2018PSPC1MT,
  title={PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis},
  author={Hsi-Wen Yeh and En-Chi Hsu and Szu-Shuo Lee and Y. D. Lang and Yuh-Charn Lin and Chieh-Yu Chang and Suz-Yi Lee and D Gu and Jou-Ho Shih and Chun-Ming Ho and Chian-Feng Chen and Chiung-Tong Chen and Pang-Hsien Tu and Ching Fung Cheng and R H Chen and Ruey-Bing Yang and Yuh-Shan Jou},
  journal={Nature Cell Biology},
  year={2018},
  volume={20},
  pages={479-491}
}
Activation of metastatic reprogramming is critical for tumour metastasis. However, more detailed knowledge of the underlying mechanism is needed to enable targeted intervention. Here, we show that paraspeckle component 1 (PSPC1), identified in an aberrant 13q12.11 locus, is upregulated and associated with poor survival in patients with cancer. PSPC1… CONTINUE READING