PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes.

@article{Gragnoli2007PSMD9GV,
  title={PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes.},
  author={Claudia Gragnoli and Jennifer Cronsell},
  journal={Journal of cellular physiology},
  year={2007},
  volume={212 3},
  pages={568-71}
}
Multiple genome-wide scans in different populations have linked the chromosome 12q24 region, known as NIDDM2 (non-insulin-dependent-diabetes, locus 2), to type 2 diabetes. Within NIDDM2 we examined the PSMD9 (proteasome modulator 9/Bridge-1) gene that encodes a PDZ-domain transcriptional coactivator of insulin production. Our goal was to identify a potential contribution of the PSMD9 gene to type 2 diabetes in Italians. We directly sequenced the entire gene PSMD9 in Italian type 2 diabetes… CONTINUE READING

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