PSF acts through the human immunodeficiency virus type 1 mRNA instability elements to regulate virus expression.

@article{Zolotukhin2003PSFAT,
  title={PSF acts through the human immunodeficiency virus type 1 mRNA instability elements to regulate virus expression.},
  author={Andrei S. Zolotukhin and Daniel Michalowski and Jenifer Bear and Sergey V. Smulevitch and Abdulmaged M Traish and Rui Peng and James Patton and Ivan N Shatsky and Barbara K Felber},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 18},
  pages={6618-30}
}
Human immunodeficiency virus type 1 (HIV) gag/pol and env mRNAs contain cis-acting regulatory elements (INS) that impair stability, nucleocytoplasmic transport, and translation by unknown mechanisms. This downregulation can be counteracted by the viral Rev protein, resulting in efficient export and expression of these mRNAs. Here, we show that the INS region in HIV-1 gag mRNA is a high-affinity ligand of p54nrb/PSF, a heterodimeric transcription/splicing factor. Both subunits bound INS RNA in… CONTINUE READING
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