PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density.

@article{Chen2015PSD95FM,
  title={PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density.},
  author={Xiaobing Chen and Jonathan M Levy and Austin Hou and Christine Winters and Rita N. Azzam and Alioscka A. Sousa and Richard Leapman and Roger A Nicoll and Thomas S. Reese},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 50},
  pages={E6983-92}
}
The postsynaptic density (PSD)-95 family of membrane-associated guanylate kinases (MAGUKs) are major scaffolding proteins at the PSD in glutamatergic excitatory synapses, where they maintain and modulate synaptic strength. How MAGUKs underlie synaptic strength at the molecular level is still not well understood. Here, we explore the structural and functional roles of MAGUKs at hippocampal excitatory synapses by simultaneous knocking down PSD-95, PSD-93, and synapse-associated protein (SAP)102… CONTINUE READING
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