PSD-95 Mediates Formation of a Functional Homomeric Kir5.1 Channel in the Brain

  title={PSD-95 Mediates Formation of a Functional Homomeric Kir5.1 Channel in the Brain},
  author={Masayuki Tanemoto and Akikazu Fujita and Kayoko Higashi and Yoshihisa Kurachi},
Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on the plasma membrane in a clustered manner, while the Kir5.1 subunit expressed alone distributed mostly in cytoplasm, probably due to rapid internalization. The binding of Kir5.1… CONTINUE READING


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