PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites.

@article{Wong2001PSAspecificAN,
  title={PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites.},
  author={Bradley K. Wong and Deborah Defeo-Jones and Richard E. Jones and Victor M. Garsky and D. M. Feng and Allen Oliff and Masato Chiba and Joan D. Ellis and Jiunn Huei Lin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2001},
  volume={29 3},
  pages={313-8}
}
Tumor-selective delivery of doxorubicin by a prostate-specific antigen (PSA)-targeted peptide conjugate prodrug of doxorubicin was demonstrated in a nude mouse xenograft model of human prostate cancer. The prodrug (referred to as doxorubicin conjugate) contains doxorubicin linked to a seven-amino acid peptide conjugate that was designed to increase delivery of doxorubicin to tumor sites through the hydrolytic properties of PSA, which prostate tumors express in high amounts. Following i.p… CONTINUE READING

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