PSA-NCAM in mammalian structural plasticity and neurogenesis

  title={PSA-NCAM in mammalian structural plasticity and neurogenesis},
  author={Luca Bonfanti},
  journal={Progress in Neurobiology},
Polysialic acid (PSA) is a linear homopolymer of alpha2-8-N acetylneuraminic acid whose major carrier in vertebrates is the neural cell adhesion molecule (NCAM). PSA serves as a potent negative regulator of cell interactions via its unusual biophysical properties. PSA on NCAM is developmentally regulated thus playing a prominent role in different forms of neural plasticity spanning from embryonic to adult nervous system, including axonal growth, outgrowth and fasciculation, cell migration… CONTINUE READING
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