PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety.

@article{Brunelli2009PRX00023AS,
  title={PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety.},
  author={Susan A Brunelli and Jessica A Aviles and Kimberly S. Gannon and Aron Branscomb and Sharon Shacham},
  journal={Pharmacology, biochemistry, and behavior},
  year={2009},
  volume={94 1},
  pages={8-15}
}
To address the development of early anxiety disorders across the lifespan, the High USV line of rats was bred based on rates of infant ultrasonic vocalization in the 40-50 kHz range of predominant frequencies (USV) to maternal separation at postnatal day (P) 10. In this study, rates of USV in High line infants (pups: Postnatal Day 11+/-1) were compared to those of randomly-bred controls in response to EPIX compound PRX-00023, a unique serotonin (5-HT) agonist, acting exclusively at the 5-HT1A… CONTINUE READING