PRSS1 mutations and the proteinase/antiproteinase imbalance in the pathogenesis of pancreatic cancer

@article{Yi2015PRSS1MA,
  title={PRSS1 mutations and the proteinase/antiproteinase imbalance in the pathogenesis of pancreatic cancer},
  author={Qiang Yi and Feng Dong and Liqing HE Lin and Qicai Liu and Shu Shin Chen and Feng Gao and Qingliang He},
  journal={Tumor Biology},
  year={2015},
  volume={37},
  pages={5805-5810}
}
This study aimed to investigate the mutations in the serine protease 1 gene (PRSS1) and the imbalance between trypsin and α1-antitrypsin in patients with pancreatic cancer. Polymerase chain reaction (PCR) was performed to amplify the sequences of PRSS1 from 65 patients with pancreatic cancer and 260 healthy controls, direct sequencing was performed, and the clinical features were analyzed. In addition, enzyme-linked immunosorbent assay (ELISA) was employed to detect serum trypsin and α1… CONTINUE READING
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