PRRT2 inhibits the proliferation of glioma cells by modulating unfolded protein response pathway.

  title={PRRT2 inhibits the proliferation of glioma cells by modulating unfolded protein response pathway.},
  author={Guanghui Bi and Jingfen Yan and Shuzhen Sun and Xin-Guo Qu},
  journal={Biochemical and biophysical research communications},
  volume={485 2},
4 Citations

Oncogenic Role of MicroRNA-30b-5p in Glioblastoma Through Targeting Proline-Rich Transmembrane Protein 2.

It is demonstrated that miR-30b promotes glioblastoma cell proliferation, migration, and invasion via targeting PRRT2, and may be used as a promising therapeutic target for gliOBlastoma.

Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

The role of negative selection in tumor evolution is re-examined through the analysis of the patterns of somatic mutations affecting the coding sequences of human genes, confirming that tumor suppressor genes are positively selected for inactivating mutations.

Estrogen Receptor α Agonist is Beneficial for Young Female Rats Against Chronic Unpredicted Mild Stress-Induced Depressive Behavior and Cognitive Deficits.

It was demonstrated hippocampal ERα is an important pro-resilient factor in CUMS-induced depressive behaviors and cognitive deficits and it was given that the neuroprotection afforded by hippocampAL ERα/Wnt interactions have significant implications for cognition and emotion in young females.



PRRT2 Mutant Leads to Dysfunction of Glutamate Signaling

The results suggest that mutant PRRT2, probably through its weakened interaction with SNAP25, affects glutamate signaling and glutamate receptor activity, resulting in the increase of glutamate release and subsequent neuronal hyperexcitability.

The evolving spectrum of PRRT2-associated paroxysmal diseases.

A comprehensive review of 1444 published cases of PRRT2-associated diseases is provided, providing a detailed assessment of the demographics, disease characteristics and genetic findings of patients withPRRT2 mutations.

MiR-30a-5p Suppresses Tumor Metastasis of Human Colorectal Cancer by Targeting ITGB3

This study provides the first evidence that miR-30a-5p suppresses colon cancer metastasis through the inhibition of ITGB3.

MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL.

The data identified miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression, which is frequently overexpressed in colorectal cancer.

MiR-30a-5p/UBE3C axis regulates breast cancer cell proliferation and migration.

MiR-30a-5p Overexpression May Overcome EGFR-Inhibitor Resistance through Regulating PI3K/AKT Signaling Pathway in Non-small Cell Lung Cancer Cell Lines

Overexpression of miR-30a-5p significantly reduced the expression of the PI3K regulatory subunit (PIK3R2) to further induce cell apoptosis, and inhibit cell invasion and migration properties, and may play vital roles in overcoming the acquired resistance to EGFR-TKIs.

ER stress and diseases

Molecules that regulate the ER stress response would be potential candidates for drug targets in various conformational diseases.