PRRT2: from Paroxysmal Disorders to Regulation of Synaptic Function

@article{Valtorta2016PRRT2FP,
  title={PRRT2: from Paroxysmal Disorders to Regulation of Synaptic Function},
  author={Flavia Valtorta and Fabio Benfenati and Federico Zara and J Meldolesi},
  journal={Trends in Neurosciences},
  year={2016},
  volume={39},
  pages={668-679}
}
In the past few years, proline-rich transmembrane protein (PRRT)2 has been identified as the causative gene for several paroxysmal neurological disorders. Recently, an important role of PRRT2 in synapse development and function has emerged. Knock down of the protein strongly impairs the formation of synaptic contacts and neurotransmitter release. At the nerve terminal, PRRT2 endows synaptic vesicle exocytosis with Ca2+ sensitivity by interacting with proteins of the fusion complex and with the… CONTINUE READING
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