PRP8 intein in Ajellomycetaceae family pathogens: sequence analysis, splicing evaluation and homing endonuclease activity.

@article{Theodoro2011PRP8II,
  title={PRP8 intein in Ajellomycetaceae family pathogens: sequence analysis, splicing evaluation and homing endonuclease activity.},
  author={Raquel Cordeiro Theodoro and Gerrit Volkmann and X Q Liu and Eduardo Bagagli},
  journal={Fungal genetics and biology : FG & B},
  year={2011},
  volume={48 2},
  pages={80-91}
}
Inteins are intervening sequences that are transcribed and translated with flanking host protein sequences and then self-excised by protein splicing. Bi-functional inteins also contain a homing endonuclease responsible for their genetic mobility. The PRP8 intein, the most widespread among fungi, occurs in important pathogens such as Histoplasma capsulatum and Paracoccidioides brasiliensis, from the Ajellomycetaceae family. Herein, we describe the bi-functional PRP8 intein in two other… CONTINUE READING