PROTS-RF: A Robust Model for Predicting Mutation-Induced Protein Stability Changes

@inproceedings{Li2012PROTSRFAR,
  title={PROTS-RF: A Robust Model for Predicting Mutation-Induced Protein Stability Changes},
  author={Yunqi Li and Jianwen Fang},
  booktitle={PloS one},
  year={2012}
}
The ability to improve protein thermostability via protein engineering is of great scientific interest and also has significant practical value. In this report we present PROTS-RF, a robust model based on the Random Forest algorithm capable of predicting thermostability changes induced by not only single-, but also double- or multiple-point mutations. The model is built using 41 features including evolutionary information, secondary structure, solvent accessibility and a set of fragment-based… CONTINUE READING

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