PROTEAN: Deriving Protein Structure from Constraints

  title={PROTEAN: Deriving Protein Structure from Constraints},
  author={Barbara Hayes-Roth and Bruce G. Buchanan and Olivier Lichtarge and Mike Hewitt and Russ B. Altman and James F. Brinkley and Craig Cornelius and Bruce S. Duncan and Oleg Jardetzky},
PROTEAN is an evolving knowledge-based system that is intended to identify the three-dimensional conformations of proteins in solution. Using a variety of empirically derived constraints, PROTEAN must identify legal positions for each of a protein’s constituent structures (e.g., atoms, amino acids, helices) in threedimensional space. In fact, because protein-structure analysis is an underconstrained problem, PROTEAN must identify the entire family of conformations allowed by available… CONTINUE READING

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