PROPYLENEGLYCOL INTOXICATION DUE TO INTRAVENOUS NITROGLYCERIN

@article{Demey1984PROPYLENEGLYCOLID,
  title={PROPYLENEGLYCOL INTOXICATION DUE TO INTRAVENOUS NITROGLYCERIN},
  author={Hendrik E. Demey and Ronny A. Daelemans and Marc E. De Broe and Leo Bossaert},
  journal={The Lancet},
  year={1984},
  volume={323}
}

Topics from this paper

Unusual D‐Lactic Acid Acidosis from Propylene Glycol Metabolism in Overdose
TLDR
Ingestion of massive doses of propylene glycol, previously not reported as a cause of D‐lactic acidosis, should be added to the differential diagnosis of this rare condition.
Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)
TLDR
An as yet unreported complication of acute renal injury due to propylene glycol toxicity in a 7-month infant treated with vitamin D stosstherapy is presented.
E-cigarettes: Safe to recommend to patients?
TLDR
E-cigarettes are unregulated nicotine delivery systems that have never been subjected to any kind of testing of safety or of efficacy as nicotine replacement therapy, and for young people who have never smoked, these devices could potentially serve as a gateway drug.
E-cigarettes: to recommend to patients?
TLDR
E-cigarettes are unregulated nicotine delivery systems that have never been subjected to any kind of testing of safety or of efficacy as nicotine replacement therapy, and for young people who have never smoked, these devices could potentially serve as a gateway drug.
A Clinical Trial Assessing the Efficacy and Safety of a New Injectable Formula of Sodium Phenobarbital Containing No Additives for the Treatment of Neonatal Seizures
TLDR
The study demonstrated that NOBELBAR® was effective for the control of neonatal seizures, and plasma drug concentrations were maintained within the therapeutic range.
Hunting down a double gap metabolic acidosis
TLDR
PG should be in the differential diagnosis of the disorders with high osmolar gap and may not always be associated with l- or d-lactic acidosis.
Effects of oral administration of a commercial activated charcoal suspension on serum osmolality and lactate concentration in the dog.
TLDR
These laboratory measures and the clinical signs of vomiting, lethargy, and increased frequency of drinking might complicate the diagnosis or monitoring of some intoxications in dogs that have previously received AC suspension containing propylene glycol, glycerol, or both as vehicles.
Hemodynamic effects of SIN-1 in acute left heart failure
TLDR
The absence of noteworthy side effects and tolerance during this prolonged administration indicate that SIN-1 is a potentially useful drug in the management of patients admitted with exacerbation of heart failure.
NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Ethylene Glycol.
  • Medicine
    NTP CERHR MON
  • 2004
TLDR
An evaluation of the potential for ethylene glycol to cause adverse effects on reproduction and development in humans found that, at high exposure levels, there is no evidence of adverse reproductive effects in mice or rats.
...
1
2
3
4
...

References

SHOWING 1-5 OF 5 REFERENCES
Hyperosmolality in small infants due to propylene glycol.
TLDR
The finding that several infants in the nursery were hyperosmolar due to administration of propylene glycol in a multivitamin preparation used in parenteral nutrition raises concern about the relatively large dose of prophene glycol that may be received by very small infants, especially those receiving multiple medications.
Hyperosmolality in the burn patient: analysis of an osmolal discrepancy.
In our study of 262 hospitalized flame burn patients, serum hyperosmolality, defined as having at least two reported osmolality values greater than 310 mOsm/kg, was observed in 15 patients (6%). From
Propylene glycol intoxication and lactic acidosis.
Toxicology, metabolism, and biochemistry of 1,2-propanediol.
  • J. Ruddick
  • Chemistry, Medicine
    Toxicology and applied pharmacology
  • 1972
TLDR
Metabolic and chronic studies demonstrate that 1,2-propanediol can be used as a substitute for carbohydrate in the diet of rats and young chicks.