PROPRANOLOL INCREASES ARTERIAL AMMONIA IN LIVER CIRRHOSIS

@article{Buuren1982PROPRANOLOLIA,
  title={PROPRANOLOL INCREASES ARTERIAL AMMONIA IN LIVER CIRRHOSIS},
  author={H. V. Buuren and G. Koorevaar and P. V. Velden and J. Silberbusch},
  journal={The Lancet},
  year={1982},
  volume={320},
  pages={951-952}
}
Propranolol (20 mg 4 times a day) was given to patients with liver cirrhosis or fatty infiltration of the liver. In six patients with cirrhosis and a stable arterial plasma ammonia concentration before treatment, blood ammonia was increased significantly on day 3 of propranolol treatment. Arterial plasma ammonia concentration was still high on day 6 of propranolol. Individual percentage change in arterial ammonia ranged from 8% to 66%. After propranolol had been discontinued ammonia… Expand
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