PROPANEDIOL METABOLISM AND ITS RELATION TO LACTIC ACID METABOLISM *

@article{Miller1965PROPANEDIOLMA,
  title={PROPANEDIOL METABOLISM AND ITS RELATION TO LACTIC ACID METABOLISM *},
  author={O. Neal Miller and Gaetano Bazzano},
  journal={Annals of the New York Academy of Sciences},
  year={1965},
  volume={119}
}
  • O. Miller, G. Bazzano
  • Published 1965
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
Interest in propanediol as related to lactate metabolism began 15 or more years ago when, in experiments with heart muscle slices, it was observed tha t lactic acid utilization by rat ventricle slices could not be completely inhibited by concentrations of sodium fluoride, which is known to block enolease activity.' Although greater amounts of lactate were utilized than could be accounted for on the basis of respiration of the heart muscle slices, this increased lactate utilization was not… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Formation in vivo of glycogen by certain intermediates of the lactate-propanediol pathway.
TLDR
This work investigated the glycogenic potency of acetol and lactaldehyde, intermediates in the conversion of 1,2-propanediol to lactate, which would be expected to be glycogenic since lactate is readily converted to glycogen. Expand
The anaerobic metabolism of pyruvate in homogenates of normal and neoplastic rat tissues.
Summary Under anaerobic conditions, glycolyzing homogenates of normal and neoplastic rat tissues were found to be capable of metabolizing pyruvate at a rapid rate to yield compounds other than lacticExpand
Phosphorylated intermediates in tumor glycolysis; isolation of phosphate esters from tumors.
TLDR
In an investigation to determine whether phosphorylated intermediates are concerned in tumor glycolysis a series of analyses was carried out for the esters and related components of the EmbdenMeyerhof glyCOlysis scheme, finding evidence that it was concerned in the metabolism of sugars and indicated that it might play a part in ribose formation. Expand
Metabolism of pyruvate in tumor homogenates.
The anaerobic glycolysis system with homogenates of Flexner-Jobling carcinoma was shown to metabolize pyruvate to reduced products other than lactate to an extent almost comparable in magnitude toExpand
PROPIONIC ACID METABOLISM: MECHANISM OF THE METHYLMALONYL ISOMERASE REACTION AND THE REDUCTION OF ACRYLYL COENZYME A TO PROPIONYL COENZYME A IN PROPIONIBACTERIA.
  • R. W. Swick
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1962
TLDR
The purified enzyme, methylmalonyl-oxalacetic transcarboxylase, has now been shown to contain this factor and it has been suggested that the reaction might involve a dehydrogenation which would weaken the bond of the formyl CoA group, permitting its translocation to the other side of the double bond. Expand
COMPARATIVE EFFECTS OF PROPYLENE GLYCOL, OTHER GLYCOLS, AND ALCOHOL ON THE LIVER DIRECTLY
1. Propylene glycol decreased the oxygen consumption and carbon dioxide production of the perfused isolated cat's liver, but increased the glycogen of the liver and the lactic acid content of theExpand
A fractionation procedure for the acid-soluble phosphorus compounds of liver.
  • J. Sacks
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1949
TLDR
The present procedure is considered to be an improvement over that of Kaplan and Greenberg in that a more complete separation of the alkaline earth-insoluble compounds from the soluble ones is achieved by the use of calcium in addition to barium than is possible with barium alone. Expand
The metabolism of 1,2-propanediol.
  • E. Huff
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 1961
TLDR
These results demonstrate a new stereospecificity of alcohol dehydrogenase involving the carbon adjacent to the one being oxidized, and the importance of using a recently described technique of bisulfite ion exchange chromatography for the separation and identification of acetol and lactaldehyde. Expand
STUDIES OF THE MECHANISM OF ACTION OF COBAMIDE COENZYMES
TLDR
Results suggested that the enzyme is capable of modifying the coenzyme, possibly by breaking the carbon-cobalt bond, and this process may reflect an important aspect of the actual catalytic process. Expand
THE METABOLISM OF LACTALDEHYDE. VI. THE REDUCTION OF D- AND L-LACTALDEHYDE IN RAT LIVER.
Abstract The partial purification from rat liver of a NAD-dependent enzymic activity, utilizing d -and l -lactaldehyde equally well, is described. 1,2-propanediol was identified as the product ofExpand
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